CNS Calculation and Verification Model

Drmike · 7th May 2006, 07:13

From another thread

Quote: (Originally Posted by saturation)

Without formal testing, its not possible to determine if a diver is oxtox prone, but USN trials suggests there were such folks. It was largely abandoned when studies suggested that tox was not dose related, as suggested by CNS clock, but more consistently related to the maximum p02 inhaled. Convulsions can occur anytime. The CNS% clock has little value.

Interesting. This falls in line with my observations. Can any of our good diving docs comment on this? Or maybe Dave could elaborate (with refferences if possible)

AD_ward9 · 7th May 2006, 11:29

Quote: (Originally Posted by Drmike)

From another thread

Interesting. This falls in line with my observations. Can any of our good diving docs comment on this? Or maybe Dave could elaborate (with refferences if possible)

The general view of the biochemistry by most researchers in this area is that O2 tox is considered a result of free radical damage at a cellular membrane level. It is therefore a good analogy to call it a "Clock", in that at a given PPO2 level, the number of radicals increases reasonably linearly with time and when they become high enough in enough cells, it results in physical CNS tox symptoms. I am travelling but when back in the office, will dig out the papers and cite them.

Cheers

Alex

7th May 2006, 07:13	#21 (permalink)
Drmike Custom Title Allowed! Current Rebreather/s: MK 15.X Ouroboros Other CCR Home Build Other Rebreather/s: Inspiration Classic Other CCR Home Build Join Date: Feb 2005 Posts: 3,287	Re: CNS Calculation and Verification Model From another thread Quote: (Originally Posted by saturation) Without formal testing, its not possible to determine if a diver is oxtox prone, but USN trials suggests there were such folks. It was largely abandoned when studies suggested that tox was not dose related, as suggested by CNS clock, but more consistently related to the maximum p02 inhaled. Convulsions can occur anytime. The CNS% clock has little value. Interesting. This falls in line with my observations. Can any of our good diving docs comment on this? Or maybe Dave could elaborate (with refferences if possible) __________________ Cave diving is a sport Wreck diving is a sport Diving in general is a sport 'Rebreather diving' is not a sport its the delusional obsession with a highly dangerous and often inappropriate piece of equipment
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7th May 2006, 11:29	#22 (permalink)
AD_ward9 So much more to learn Current Rebreather/s: Other CCR Other Rebreather/s: Other CCR Join Date: Jun 2005 Location: Scotland Posts: 1,853	Re: CNS Calculation and Verification Model Quote: (Originally Posted by Drmike) From another thread Interesting. This falls in line with my observations. Can any of our good diving docs comment on this? Or maybe Dave could elaborate (with refferences if possible) The general view of the biochemistry by most researchers in this area is that O2 tox is considered a result of free radical damage at a cellular membrane level. It is therefore a good analogy to call it a "Clock", in that at a given PPO2 level, the number of radicals increases reasonably linearly with time and when they become high enough in enough cells, it results in physical CNS tox symptoms. I am travelling but when back in the office, will dig out the papers and cite them. Cheers Alex
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