Alternate PFO Treatment

bendomatic · 25th August 2007, 05:12

Quote: (Originally Posted by debersole)

As a cardiologist who percutaneously closes PFOs on a regular basis, I found the study interesting when it was published in Circulation. However, as mentioned above it is a "first in man" pilot study. If I had a PFO and needed it closed I would go with one of the currently approved devices that has a long track record of safety and efficacy. The bioabsorbable product is interesting, but needs a lot more investigation.

is Circulation considered a good journal for this sort of publication. does it have good peer review?

it looks promising. obviously for a few there is the issue of size. i wonder if there are plans to make any bigger ones. from my wanderings around the internet, IF (and that's a big IF) antibodies were raised against the pig collagen, then it could react with human collagen. i wonder how antigenic in reality collagen would be, given that thousands of women inject into their faces etc around the world. this kind of partially answers my own question. allergic reactions to bovine collagen is documented. Aust N Z J Ophthalmol. 1996 Aug;24(3):257-60. perhaps screening prior to procedure?
while i work with immunologists i'm not, so these are just my ponderings.

Also one of the justifications for the development of this product is the later possibility of further Left atrium surgery/procedure that isn't possible with current devices. is it really a concern, that the current devices interfere with treatment later? even this device has nitinol springs/framework so it will still be present til well after you've left this mortal coil.

rachel
PS. you're welcome Dave, it was my pleasure!

Mdemon · 25th August 2007, 07:53

Very interesting!

Could the Docs speculate whether if this new thing failed, a normal closure could be used afterwards?

25th August 2007, 05:12	#11 (permalink)
bendomatic Morgan's Mum Current Rebreather/s: Sport Kiss Other Rebreather/s: Join Date: Apr 2005 Location: Brisbane Australia Posts: 205	Re: Alternate PFO Treatment Quote: (Originally Posted by debersole) As a cardiologist who percutaneously closes PFOs on a regular basis, I found the study interesting when it was published in Circulation. However, as mentioned above it is a "first in man" pilot study. If I had a PFO and needed it closed I would go with one of the currently approved devices that has a long track record of safety and efficacy. The bioabsorbable product is interesting, but needs a lot more investigation. is Circulation considered a good journal for this sort of publication. does it have good peer review? it looks promising. obviously for a few there is the issue of size. i wonder if there are plans to make any bigger ones. from my wanderings around the internet, IF (and that's a big IF) antibodies were raised against the pig collagen, then it could react with human collagen. i wonder how antigenic in reality collagen would be, given that thousands of women inject into their faces etc around the world. this kind of partially answers my own question. allergic reactions to bovine collagen is documented. Aust N Z J Ophthalmol. 1996 Aug;24(3):257-60. perhaps screening prior to procedure? while i work with immunologists i'm not, so these are just my ponderings. Also one of the justifications for the development of this product is the later possibility of further Left atrium surgery/procedure that isn't possible with current devices. is it really a concern, that the current devices interfere with treatment later? even this device has nitinol springs/framework so it will still be present til well after you've left this mortal coil. rachel PS. you're welcome Dave, it was my pleasure! __________________ why deal with idiots on the net when you have to spend all day dealing with them at work. Last edited by bendomatic : 25th August 2007 at 05:18.
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25th August 2007, 07:53	#12 (permalink)
Mdemon SiegeEngine II Current Rebreather/s: Inspiration Classic Home Build Other Rebreather/s: Inspiration Classic Home Build Join Date: Feb 2007 Location: SWUK Posts: 1,927	Re: Alternate PFO Treatment Very interesting! Could the Docs speculate whether if this new thing failed, a normal closure could be used afterwards? __________________ www.southwestmafia.com "small minds talk about people, Average Minds Talk About Events, GREAT MINDS TALK ABOUT IDEAS!" The WRONG Attitude will get you killed. "Once the agenda-monkeys and perfect-worlders have moved on, perhaps we can do some diving?"
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