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Seizure threshold & Rebreather diving deaths



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Old 9th April 2006, 10:45   #11 (permalink)
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Re: Seizure threshold & Rebreather diving deaths

Is there any milage in considering the UK wartime system for selecting oxygen rebreather divers? AIUI They put you into the suit and took you to 45 feet (about 2.5bar) and waited. If nothing happened you proceded with training. If you woke up back on the dock you were assigned to other duties. The one exposure test was deemed sufficient although 'war time' admittedly does change the rules a bit.
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Old 9th April 2006, 14:10   #12 (permalink)
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Re: Seizure threshold & Rebreather diving deaths

Quote: (Originally Posted by abowie)
Seizures.


This statement differs somewhat from Lambertsen's description quoted in Bennett and Elliott on page 376 of the current edition of a "tonic-clonic seizure..usually followed by 5 to 30 minutes of gradual recovery of mental alertness".

On the next page in the section entitled "Changes in Brain Electrical Activity" it is stated that "seizure activity was associated with generalised electrical discharges, gross EEG activity" although EEG activity was not "consistently altered proir to the actual event". This seems to be backed up by other research.
To clarify, terminology tends to be troublesome and the manifestations of seizures, varied.

http://medlib.med.utah.edu/neuronet/epi/filloux1.html

Convulsions is a term commonly used in diving medicine to reflect findings in CNS studies and to emphasize a lack of a CNS abnormality associated with hyperoxic seizures.

Alas, in general medical usage the term seizures is synonymous with convulsions, which is troublesome as the term seizures is also used to classify true CNS related diseases.

Normal folks can be induced to seize with hypoxia, hypoglycemia, hyperoxia, ECT or head trauma etc., and you can clearly get a specific EEG finding at the time of the convulsion ... just as you can read EEG findings characteristic of sleep, mental activity or under CNS altering drugs. However in a true CNS focus, as example epilelpsy, an abnormality can detected consistently in seizure free periods.

That said, Bennett & Elliott do not conclude, but give the facts as they existed at time of publication.

In the next page, p378, based on human studies, a linked included here ends that section:

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum
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Old 9th April 2006, 14:16   #13 (permalink)
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Re: Seizure threshold & Rebreather diving deaths

Quote: (Originally Posted by Sutty)
Just found this on the Gap software pages on the web "Current thoughts on mechanisms of hyperoxic seizures" which may be of interest.
A nice summary, although I am not very fond of biochemical mechanisms as they often conflict with clinical findings, while taking the reader on convoluted and not entirely practical path.

While alluded in association with sleep states, the biochemical focus obviates a key item: that is the effects of sedation in reducing cathecholamine release in reducing the risk for hyperoxic seizures. In practical terms, this means increasing the PN2 of a mix, as narcosis produces a calming effect that is removed by having too rich helium in mixes [ thus the recommendation of a lower P02 threshold in helium mixed gases].
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Old 9th April 2006, 18:21   #14 (permalink)
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Re: Seizure threshold & Rebreather diving deaths

Quote: (Originally Posted by nigelh)
Is there any milage in considering the UK wartime system for selecting oxygen rebreather divers? AIUI They put you into the suit and took you to 45 feet (about 2.5bar) and waited. If nothing happened you proceded with training. If you woke up back on the dock you were assigned to other duties. The one exposure test was deemed sufficient although 'war time' admittedly does change the rules a bit.
The US Navy did this for years with their divers. Put them in a chamber at 3 bar and if anyone got symptoms (as if they would admit it!) they were out. They gave up for the simple reason that it proved to be a poor screening test, with low sensitivity and a very low positive predictive value.

One thing Donald (whose work you allude to) clearly demonstrated during the war was that an individual's susceptibility varied considerably from day to day. He concluded that the only useful preventive strategy was to limit exposure in everyone.

For anyone who hasn't read his book 'Oxygen and the Diver', I suggest they do. It has more directly obtained experimental evidence about oxygen toxicity in diving than any other work, and his work is unlikely to be repeated due to modern ethical constraints.

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Old 9th April 2006, 19:20   #15 (permalink)
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Re: Seizure threshold & Rebreather diving deaths

Quote: (Originally Posted by saturation)
On this board, jhaaja report is detailed and complete, and he was conscious:

http://www.rebreatherworld.com/rebre...onvulsion.html
Don`t know eaxtly what you meant by being consciouss. I lost its just before i got the OC reg in ny mouth and came back aroun on the boat deck maybe 30mins after the hit.

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Old 10th April 2006, 18:16   #16 (permalink)
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Re: Seizure threshold & Rebreather diving deaths

Quote: (Originally Posted by jhaaja)
Don`t know eaxtly what you meant by being consciouss. I lost its just before i got the OC reg in ny mouth and came back aroun on the boat deck maybe 30mins after the hit.

JH
Hi JH, sorry my mistake .. faulty memory on my part.

Per the link, as you wrote, you lost consciousness at the time of the 02 convulsion. My mistake again.
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